Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications
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Date
2016-08
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International Journal of Pharmaceutics.
Abstract
Advancement in the field of nanoscience and technology has alarmingly raised the call for
comprehending the potential health effects caused by deliberate or unintentional exposure to
nanoparticles. Iron oxide magnetic nanoparticles have an increasing number of biomedical applications
and hence a complete toxicological profile of the nanomaterial is therefore a mandatory requirement
prior to its intended usage to ensure safety and to minimize potential health hazards upon its exposure.
The present study elucidates the toxicity of in house synthesized Dextran stabilized iron oxide
nanoparticles (DINP) in a regulatory perspective through various routes of exposure, its associated
molecular, immune, genotoxic, carcinogenic effects and bio distribution profile. Synthesized ferrite
nanomaterials were successfully coated with dextran (<25 nm) and were physicochemically
characterized and subjected to in vitro and in vivo toxicity evaluations. The results suggest that surface
coating of ferrite nanoparticles with dextran helps in improvising particle stability in biological
environments. The nanoparticles do not seem to induce oxidative stress mediated toxicological effects,
nor altered physiological process or behavior changes or visible pathological lesions. Furthermore no
anticipated health hazards are likely to be associated with the use of DINP and could be concluded that
the synthesized DINP is nontoxic/safe to be used for biomedical applications
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Keywords
Dextran stabilized iron oxide nanoparticle Biocompatibility Genotoxicity Oral toxicity Dermal toxicity Bio distribution
Citation
Remya N S, Syama S, Sabareeswaran A, Mohanan P V. Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications. International Journal of Pharmaceutics. 2016;511(1):586-98.