Alterations in collagen metabolism and increased fibroproliferation in the heart in cerium-treated rats: implications for the pathogenesis of endomyocardial fibrosis.

dc.contributor	Prakash Kumar, B
dc.contributor	Shivakumar, K
dc.date.accessioned	2012-12-04T11:43:21Z
dc.date.available	2012-12-04T11:43:21Z
dc.date.issued	1998
dc.description.abstract	Cerium (Ce), a rare earth element, has been postulated to play a role in the pathogenesis of tropical endomyocardial fibrosis (EMF). Investigations carried out recently in pursuance of the postulation furnished histological evidence of EMF and increased cardiac collagen content in rats on prolonged administration of Ce. The present study was undertaken to understand the molecular basis of myocardial injury and fibrosis produced by the element. This article presents evidence of increased lipid peroxidation and elevated rates of fibroblast proliferation and collagen deposition in the heart in Ce-treated rats. It is suggested that the element may trigger a wound-healing response in the cardiac tissue leading to cardiac fibrosis.
dc.identifier.citation	Biological trace element research. 63; 1; 73-9	en_US
dc.identifier.uri	https://dspace.sctimst.ac.in/handle/123456789/94
dc.publisher	Biological trace element research
dc.subject	Biochemistry
dc.title	Alterations in collagen metabolism and increased fibroproliferation in the heart in cerium-treated rats: implications for the pathogenesis of endomyocardial fibrosis.