Supramolecular hydroxyapatite complexes as theranostic near-infrared luminescent drug carriers
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Date
2014-07
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CrystEngComm
Abstract
The facile synthesis of luminescent, multifunctional, needle-like hydroxyapatite (HA) nanoparticle
complexes containing cyclodextrin has been reported. The in vitro loading and release studies using
doxorubicin hydrochloride (DOX) demonstrate that the nanoparticle complexes show high drug adsorption
capacity and sustained drug release profiles. Moreover, they exhibit strong photoluminescence even after
loading of DOX molecules and permit the monitoring of the photoluminescence intensity. The nanocomplexes
further reveal excellent blood compatibility, inappreciable toxicity and cellular internalization
properties. Upon excitation at 420 nm, these complexes exhibit strong near-infrared emission at 680 nm.
The photoluminescence intensity of the nanoparticles can be adjusted by varying the concentration of
neodymium. Thus, the nanoparticle complexes obtained in the present study are promising for applications
in the biomedical field as multifunctional drug delivery systems for simultaneous targeted drug delivery and
near-infrared fluorescence imaging guidance.
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CrystEngComm,. 2014;16:9033-42.