Pathological Effects of Processed Bovine Pericardial ScaffoldsA Comparative In Vivo Evaluation

Simple item page
dc.contributor.authorThampi, P
dc.contributor.authorNair, D
dc.contributor.authorLalithakunjamma, R
dc.contributor.authorVijayan, N
dc.contributor.authorVenugopal, S
dc.contributor.authorRamachandra, U
dc.date.accessioned2017-03-10T03:27:55Z
dc.date.available2017-03-10T03:27:55Z
dc.date.issued2013
dc.description.abstractThe objective of the present study was to assess the biocompatibility and regenerative potential of decellularized bovine pericardial scaffold in comparison with glutaraldehyde-treated and fresh bovine pericardial implants using short-term intramuscular implantation testing in a rat model. The inflammatory and immune responses were assessed using histopathological examination, special stains for connective tissue, histomorphometric evaluation, and immunohistochemistry. The decellularized pericardium showed an active tissue remodeling response with complete cellular invasion, minimum connective tissue encapsulation, extensive fibrovascular tissue formation, and collagen deposition. On the contrary, the glutaraldehyde-treated pericardial implants showed incomplete degradation and cellular invasion, while the fresh pericardial implants elicited a severe foreign body reaction. The results of immunohistochemical staining revealed a minimum T helper (CD4+) lymphocyte response in decellularized pericardial implants compared with its glutaraldehyde-treated and fresh counterparts. The decellularized bovine pericardium was better accepted as a prosthetic scaffold, which permitted maximum collagen deposition and active tissue remodeling by invading host cells and showed good tissue integration in vivo compared with glutaraldehyde-treated and fresh/untreated pericardium.
dc.identifier.citation37 ,7;600-605en_US
dc.identifier.uri10.1111/aor.12050
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10188
dc.publisherARTIFICIAL ORGANS
dc.subjectEngineering; Transplantation
dc.titlePathological Effects of Processed Bovine Pericardial ScaffoldsA Comparative In Vivo Evaluation
Files
Collections
Journal Articles