Serum tumor necrosis factor-alpha in Guillain-Barre syndrome and its relation to plasma exchange

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dc.contributorReuben, S
dc.contributorMathai, A
dc.contributorGeorge, SM
dc.contributorNair, MD
dc.contributorRadhakrishnan, VV
dc.date.accessioned2012-12-04T11:45:12Z
dc.date.available2012-12-04T11:45:12Z
dc.date.issued2002
dc.description.abstractBACKGROUND- To correlate the serum tumor necrosis factor-alpha (TNFalpha) concentrations before, during and following plasma exchange in patients with Guillain-Barre syndrome (GBS). In this prospective study, 21 GBS patients were selected. Patients in clinical stages III to V were subjected to plasma exchange. The control group included equal numbers of age-matched patients with other neurological diseases and healthy voluntary blood donors. A sandwich ELISA method was applied to estimate serum TNFalpha concentrations in test and control groups.REVIEW SUMMARY-Twelve GBS patients had elevated serum TNFalpha levels that ranged between 74 and 182 pg/mL. All 12 GBS patients showed a steady decrease in the TNFalpha concentration following plasma exchange and also showed a positive correlation with neurological recovery.CONCLUSIONS- We conclude that serum TNFalpha concentrations are elevated in 57.1 % of GBS patients and TNFalpha level decreases following plasma exchange.
dc.identifier.citationNEUROLOGIST. 8; 1; 47-50en_US
dc.identifier.urihttp://dx.doi.org/10.1097/00127893-200201000-00006
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/1036
dc.publisherNEUROLOGIST
dc.subjectNeurology
dc.titleSerum tumor necrosis factor-alpha in Guillain-Barre syndrome and its relation to plasma exchange
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