Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis.

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dc.contributorBalan, Shabeesh
dc.contributorVellichirammal, Neetha Nanoth
dc.contributorBanerjee, Moinak
dc.contributorRadhakrishnan, Kurupath
dc.date.accessioned2012-12-04T11:44:07Z
dc.date.available2012-12-04T11:44:07Z
dc.date.issued2012
dc.description.abstractWe compared the allele and genotype frequencies of SCN1A SNP rs3812718 between patients with MTLE-HS of south Indian ancestry with and without febrile seizures (FS) and with ethnically matched controls. While we observed no significant difference in allele and genotype frequencies of rs3812718 between MTLE-HS patients with and without FS, A allele and AA genotype were overrepresented in MTLE-HS patients when compared to controls. We conclude that in the population studied, although rs3812718 polymorphism increases the susceptibility to MTLE-HS, this is not by increasing the susceptibility to FS.
dc.identifier.citationEpilepsy research. 101; 3; 288-92en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.eplepsyres.2012.04.009
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/499
dc.publisherEpilepsy research
dc.titleFailure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis.
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