Diagnostic utility of polymerase chain reaction and immunohistochemical techniques for the laboratory diagnosis of intracranial tuberculoma

Simple item page
dc.contributorSumi, MG
dc.contributorMathai, A
dc.contributorSheela, R
dc.contributorRadhakrishnan, NS
dc.contributorRadhakrishnan, VV
dc.contributorIndhulekshmy, R
dc.contributorMundayoor, S
dc.date.accessioned2012-12-04T11:43:51Z
dc.date.available2012-12-04T11:43:51Z
dc.date.issued2001
dc.description.abstractIn an attempt to establish a tuberculous etiology, polymerase chain reaction (PCR) and immunohistochemical (IHC) methods were undertaken in formalin-fixed paraffin sections of ten surgical specimens of intracranial tuberculoma. The control group included an equal number of intracranial fungal granuloma. Both PCR and IHC methods did not yield false-positive results in fungal granuloma. PCR was found to be less sensitive (60%) than IHC method (80%) in this study. IHC method definitely possesses several operational advantages over PCR and is more suited to laboratories in developing countries for establishing a tuberculous etiology particularly in those patients in whom the conventional bacteriological methods did not confirm the diagnosis of tuberculoma.
dc.identifier.citationCLINICAL NEUROPATHOLOGY. 20; 4; 176-180en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/11495007
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/362
dc.publisherCLINICAL NEUROPATHOLOGY
dc.subjectImmunology
dc.titleDiagnostic utility of polymerase chain reaction and immunohistochemical techniques for the laboratory diagnosis of intracranial tuberculoma
Files
Collections
Journal Articles