INVIVO BIOCOMPATIBILITY OF AN ALIPHATIC CROSS-LINKED POLYURETHANE IN RABBIT

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dc.contributorJAYABALAN, M
dc.contributorKUMAR, NS
dc.contributorRATHINAM, K
dc.contributorKUMARI, TV
dc.date.accessioned2012-12-04T11:44:26Z
dc.date.available2012-12-04T11:44:26Z
dc.date.issued1991
dc.description.abstractA cage implantation technique has been adopted in a rabbit animal model to investigate the biocompatibility of an aliphatic crosslinked polyurethane based on hexamethylene diisocyanate (HDI). In this study, four cages are represented; the cage containing the candidate polyurethane material, biomedical grade polyurethane (Tecoflex), the commercial grade polyvinylchloride (PVC), and an empty cage which were implanted subcutaneously in rabbits. Exudates were aspirated from these cages at 4, 7, 14, and 21 days postimplantation. Exudates were analyzed for variations in proteins, cell counts, and extracellular enzymes. Results with the four types of cage implants showed that the candidate polyurethane caused an inflammatory response comparable to that caused by medical-grade Tecoflex and the empty cage control.
dc.identifier.citationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH. 25; 12; 1431-1442en_US
dc.identifier.urihttp://dx.doi.org/10.1002/jbm.820251203
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/663
dc.publisherJOURNAL OF BIOMEDICAL MATERIALS RESEARCH
dc.subjectBiocompatibility
dc.titleINVIVO BIOCOMPATIBILITY OF AN ALIPHATIC CROSS-LINKED POLYURETHANE IN RABBIT
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