Multifunctional amino functionalized graphene quantum dots wrapped upconversion nanoparticles for photodynamic therapy and X-ray CT imaging.

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dc.contributor.authorAnjusha, AJ
dc.contributor.authorThirunavukkarasu, S
dc.contributor.authorResmi, AN
dc.contributor.authorJayasree, RS
dc.contributor.authorDhanapandian, S
dc.contributor.authorKrishnakumar, N
dc.date.accessioned2023-03-29T08:47:31Z
dc.date.available2023-03-29T08:47:31Z
dc.date.issued2023-03
dc.description.abstractHerein, we designed and developed a multifunctional nanocomposites by complexing NaGdF4:Yb/Er nanoparticles (UCNPs) with amino functionalized graphene quantum dots (af-GQDs). In the as-prepared nanocomposite (af-GQD/UCNPs), properties of UCNPs and af-GQDs were incorporated into a single nanoplatform to endow therapeutic and diagnostic functions. The UCNPs were employed as an imaging probe and a contrast agent for CT imaging, and the af-GQDs served as a therapeutic agent and photosensitizer (PS) by generating singlet oxygen for photodynamic therapy (PDT). Furthermore, the nanocomposites were investigated by electron microscopy, FTIR spectroscopy, zeta potential measurement, UV–vis spectroscopy, upconversion luminescence measurement, and cytotoxicity assessment. The in vitro experiments displayed excellent X-ray attenuation ability and PDT effects of af-GQD/UCNPs. Hence, the proposed multifunctional nanocomposites, which possesses upconversion luminescence, photodynamic, and X-ray attenuation properties, might be a viable option for application in bio-imaging and photodynamic therapy.en_US
dc.identifier.citationAnjusha AJ, Thirunavukkarasu S, Resmi AN, Jayasree RS, Dhanapandian S, Krishnakumar N. Multifunctional amino functionalized graphene quantum dots wrapped upconversion nanoparticles for photodynamic therapy and X-ray CT imaging. Inorganic Chemistry Communications,2023 Mar;149: 110428en_US
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2023.110428
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/11266
dc.publisherInorganic Chemistry Communications,en_US
dc.titleMultifunctional amino functionalized graphene quantum dots wrapped upconversion nanoparticles for photodynamic therapy and X-ray CT imaging.en_US
dc.typeArticleen_US
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