ORAL SUSTAINED-RELEASE DRUG DELIVERY SYSTEMS USING POLYCARBONATE MICROSPHERES CAPABLE OF FLOATING ON THE GASTRIC FLUID

Simple item page
dc.contributorTHANOO, BC
dc.contributorSUNNY, MC
dc.contributorJAYAKRISHNAN, A
dc.date.accessioned2012-12-04T11:44:46Z
dc.date.available2012-12-04T11:44:46Z
dc.date.issued1993
dc.description.abstractPolycarbonate microspheres loaded with aspirin, griseofulvin and p-nitroaniline were prepared by a solvent evaporation technique. High drug loading (> 50%) was achieved by this process. Drug-loaded microspheres were found to float on simulated gastric fluid and intestinal fluid. Drug-release studies were carried out in these fluids at 37-degrees-C. Increasing the drug to polymer ratio in the microspheres increased both their mean particle size and the release rate of the drugs. It was concluded that sustained delivery of drugs could be effected using this matrix.
dc.identifier.citationJOURNAL OF PHARMACY AND PHARMACOLOGY. 45; 1; 21-24en_US
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/823
dc.publisherJOURNAL OF PHARMACY AND PHARMACOLOGY
dc.titleORAL SUSTAINED-RELEASE DRUG DELIVERY SYSTEMS USING POLYCARBONATE MICROSPHERES CAPABLE OF FLOATING ON THE GASTRIC FLUID
Files
Collections
Journal Articles