Bioactive, mechanically favorable and biodegradable copolymer nanocomposites for orthopedic applications

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dc.contributor.authorVictor, SP
dc.contributor.authorJayabalan, M
dc.date.accessioned2015-01-08T08:39:55Z
dc.date.available2015-01-08T08:39:55Z
dc.date.issued2014-06
dc.description.abstractWe report the synthesis of mechanically favorable, bioactive, and biodegradable copolymer nanocomposites for potential bone applications. The nanocomposites consist of in situ polymerized biodegradable copolyester with hydroxyapatite (HA). Biodegradable copolyesters comprise carboxy terminated poly(propylene fumarate) (CT-PPF) and poly(trimethylol propane fumarate co mannitol sebacate) (TF-Co-MS). Raman spectral imaging clearly reveals a uniform homogenous distribution of HA in the copolymer matrix. The mechanical studies reveal that improved mechanical properties formed when crosslinked with methyl methacrylate (MMA) when compared to N-vinyl pyrrolidone (NVP). The SEM micrographs of the copolymer nanocomposites reveal a serrated structure reflecting higher mechanical strength, good dispersion, and good interfacial bonding of HA in the polymer matrix. In vitro degradation of the copolymer crosslinked with MMA is relatively more than that of NVP and the degradation decreases with an increase in the amount of the HA filler. The mechanically favorable and degradable MMA based nanocomposites also have favorable bioactivity, blood compatibility, cytocompatibility and cell adhesion. The present nanocomposite is a more promising material for orthopedic applications.en_US
dc.identifier.citationJ. of Mater. Sci and Engg C. 2014;39(1):150-60.en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.msec.2014.02.031
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2293
dc.publisherJ. of Mater. Sci and Enggen_US
dc.subjectBiocompatibility; Biodegradation; In situ polymerized polymeric nanocompositesen_US
dc.titleBioactive, mechanically favorable and biodegradable copolymer nanocomposites for orthopedic applicationsen_US
dc.typeArticleen_US
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