Browsing by Author "Anitha, Y"

Now showing 1 - 3 of 3
  • Item
    Alginate encapsulated bioadhesive chitosan microspheres for intestinal drug delivery
    (JOURNAL OF BIOMATERIALS APPLICATIONS, 1999) Ramdas, M; Dileep, KJ; Anitha, Y; Paul, W; Sharma, CP
    Sustained intestinal delivery of drugs such as Ei-fluorouracil (choice for colon carcinomas) and insulin (for diabetes mellitus) seems to be a feasible alternative to injection therapy. For successful therapy, the drug should be delivered at proper sites (here, the intestine) for long duration, for producing maximum pharmacological activity. We have attempted to develop a formulation that can bypass the acidity of the stomach and release the loaded drug for long periods into the intestine by using the bioadhesiveness of polyacrylic acid, alginate, and chitosan. Bromothymol blue was taken as a model drug. The formulation exhibited bioadhesive property and released the drug for an eight-day period in vitro.
  • Item
    In vivo absorption studies of insulin from an oral delivery system
    (DRUG DELIVERY, 2001) Jerry, N; Anitha, Y; Sharma, CP; Sony, P
    Alginate microspheres prepared by an emulsion-based process were loaded with insulin by a remote loading process. We observed that the time of exposure, pH of the remote loading medium, and beta -cyclodextrin complexation of insulin influenced drug loading. In vivo absorption studies of insulin from optimized microspheres were carried out in diabetic albino rats. Serum sugar levels on administration of multiple oral doses of the microspheres and a radioimmunoassay for serum insulin indicated absorption of insulin from the gastrointestinal region. This process could be utilized for the development of an oral insulin delivery system.
  • Item
    Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats
    (JOURNAL OF MICROENCAPSULATION, 2000) Ramadas, M; Paul, W; Dileep, KJ; Anitha, Y; Sharma, CP
    An oral formulation based on liposome encapsulated alginate-chitosan gel capsules was developed for insulin delivery for the treatment of diabetes. Liposome encapsulation helped to increase the encapsulation efficiency of insulin in alginate-chitosan capsules. This formulation delivers insulin in the neutral environment of the intestine, by-passing the acidic media in the stomach, with increased drug absorption and bioavailability. Oral administration of this formulation was found to reduce blood glucose levels when tested in diabetic rats.