Browsing by Author "Babu, S"

Now showing 1 - 3 of 3
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    A functional hydrogel for regeneration of nucleus pulposus
    (JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2014) Roudmiane, MM; Babu, S; Varma, HK; John, A
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    Osteogenesis of a Bioactive Ceramic-Calcium Phosphosilicate Composite System in Goat Femur Defect
    (INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2011) John, A; Mani, S; Gopalakrishnan, S; Babu, S; Lal, AV; Varma, H
    In spite of the array of synthetic bone grafts available, the pursuit for an ideal graft continues. In view of this, a synthetic bioactive calcium phosphosilicate composite (HABGS) has been developed combining the properties of hydroxyapatite and silicate system. The in vivo performance of HABGS granules in goat femur defect stimulated a favorable environment for de novo bone formation with faster resorption. The ceramic composite is attractive for its low Si content together with its negligible levels at implanted sites and vital organs postimplantation. Herein, we propose the safety and efficacy of this composite as a promising bone substitute.
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    Triphasic ceramic scaffold in paediatric and adolescent bone defects
    (JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B, 2014) Balakumar, B; Babu, S; Varma, HK; Madhuri, V
    We evaluated novel triphasic hydroxyapatite tricalcium phosphate calcium silicate scaffold (HASi) in the management of paediatric bone defects. Their main advantage is considered to be adequate strength and stimulation of bone formation without resorting to autograft. A total of 42 children younger than 16 years of age were recruited over a period of 1 year and were treated with this synthetic bone substitute as a stand-alone graft for pelvic, femur, calcaneal and ulnar osteotomies, cystic bone lesions, subtalar arthrodesis and segmental bone defects. Forty children, 22 boys and 18 girls, mean age 8.3 years and a mean follow-up of 18.51 months, were available for evaluation. Analysis showed that younger age, cancellous defects and no internal fixation were associated with significantly faster healing. Partial incorporation was observed in 22.5% and complete incorporation in 77.5% of cases at 18 months of follow-up. Sex, type of defect, BMI and the shape of the ceramic graft did not significantly affect the rate of healing. Complications attributable to HASi included four nonunions, three of which were diaphyseal. HASi was found to be safe in children with cancellous or benign cavitatory defects. It is not suitable for diaphyseal and segmental bone defects as a stand-alone graft.