Browsing by Author "Gopalakrishnan, S"

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    Osteogenesis of a Bioactive Ceramic-Calcium Phosphosilicate Composite System in Goat Femur Defect
    (INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2011) John, A; Mani, S; Gopalakrishnan, S; Babu, S; Lal, AV; Varma, H
    In spite of the array of synthetic bone grafts available, the pursuit for an ideal graft continues. In view of this, a synthetic bioactive calcium phosphosilicate composite (HABGS) has been developed combining the properties of hydroxyapatite and silicate system. The in vivo performance of HABGS granules in goat femur defect stimulated a favorable environment for de novo bone formation with faster resorption. The ceramic composite is attractive for its low Si content together with its negligible levels at implanted sites and vital organs postimplantation. Herein, we propose the safety and efficacy of this composite as a promising bone substitute.
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    Supraglottic Airway Devices and Effect on Voice-Comparison of LMA Proseal and i-gel: Double-Blind Randomized Clinical Trial
    (JOURNAL OF VOICE, 2016) Vaidya, S; Kundra, P; Gopalakrishnan, S; Parida, P; Yuvaraj, K; Mohan, PM
    Objectives. Laryngeal mask airway (LMA) is an important alternative to endotracheal intubation for all professional voice users undergoing surgery. However, dysphonia is a known complication of LMA Proseal (PLMA) use. The i-gel airway (IGA) provides adequate airway seal without the need for an inflatable cuff. Hence, it helps to minimize the risk of tissue compression. This study compares effect of PLMA and IGA on voice at 24th hour after anesthesia. Design. This is a double-blind randomized clinical trial. Methods. Ninety anesthesiologists class 1 adults scheduled for surgeries lasting up to 60-120 minutes were included in the study. Participants were randomly allocated to group PLMA (n = 43) and group IGA (n = 43). Cuff pressure was monitored and maintained at just seal pressure in group PLMA. Voice was evaluated using perceptive and acoustic analysis (jitter, shimmer, and harmonics-to-noise ratio [HNR]) preoperatively and at 24th hour after anesthesia. Voice of patients with pharyngolaryngeal complaints was categorized into rough, breathy, asthenic, strain, or normal pattern. Results. Acoustic parameters jitter, shimmer, and HNR deteriorated significantly in both group PLMA and IGA albeit the change being comparable. Incidence of pharyngolaryngeal complaints was similar in both the groups. A total of 10% patients in group PLMA and 12.5% in group IGA developed breathy voice significant deterioration in all acoustic variables at 24th postoperative hour, but differences were not significant between group PLMA and group IGA. Conclusions. PLMA and IGA both produce comparable and significant deterioration in acoustic variables at 24th hour after short duration general anesthesia.