Browsing by Author "Kaushik, MK"

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    Glutamate microinjection at the medial preoptic area enhances slow wave sleep in rats
    (BEHAVIOURAL BRAIN RESEARCH, 2011) Kaushik, MK; Kumar, VM; Mallick, HN
    A large body of evidence has established the role of the medial preoptic area (mPOA) in regulation of slow wave sleep (SWS). Although the mPOA neurons contain excitatory neurotransmitter glutamate, its role in sleep-wakefulness is not known. In the present study microinjection of monosodium glutamate (40, 80 and 120 ng) into the mPOA augmented SWS. Earlier reports have shown enhancement of paradoxical sleep by glutamate in other brain areas. (C) 2010 Elsevier B.V. All rights reserved.
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    Glutamate microinjection in the medial septum of rats decreases paradoxical sleep and increases slow wave sleep
    (NEUROREPORT, 2012) Mukherjee, D; Kaushik, MK; Jaryal, AK; Kumar, VM; Mallick, HN
    The role of the medial septum in suppressing paradoxical sleep and promoting slow wave sleep was suggested on the basis of neurotoxic lesion studies. However, these conclusions need to be substantiated with further experiments, including chemical stimulation studies. In this report, the medial septum was stimulated in adult male rats by microinjection of L-glutamate. Sleep-wakefulness was electrophysiologically recorded, through chronically implanted electrodes, for 2 h before the injection and 4 h after the injection. There was a decrease in paradoxical sleep during the first hour and an increase in slow wave sleep during the second hour after the injection. The present findings not only supported the lesion studies but also showed that the major role of the medial septum is to suppress paradoxical sleep. NeuroReport 23:451-456 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.