Browsing by Author "Mani, S"

Now showing 1 - 6 of 6
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    Adult Stem Cells on Methacrylic Acid Grafted Cocoon Silky Fibrous Scaffolds
    (Trends in Biomaterials & Artificial Organs., 2010) Mani, S; Nair, MB; Nisha, S; Sreenivasan, K; Jacob, M; John, A
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    Blade and balloon atrial septostomy for creation of an adequate interatrial communication.
    (Indian heart journal, 1994)
    During a 7 year period from 1984 to 1991, 100 infants underwent either balloon atrial septostomy (BAS) (n = 92) or blade septostomy (BLS) (n = 8). The indication was complete transposition of the great arteries in all the patients. The mean age in the BAS group was 1.8 +/- 1.5 months while that in the infants requiring BLS due to a thick septum was 3.03 +/- 2.29 months. The degree of improvement in arterial oxygen saturation in both groups was satisfactory -27.16 +/- 14.06% in the BAS group vs 23.5 +/- 12.18% in the BLS group. There were no procedure related deaths in the BLS group, through only monoplane fluoroscopy was used in 6/8 patients. Three patients however died following balloon septostomy. We conclude that BLS is a safe and effective alternative to surgical septostomy when performed with due care. Two dimensional echocardiography during BAS enhances the speed and safety of the procedure and helps to identify patients who may require BLS due to a thick interatrial septum.
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    Nanohydroxyapatite Incorporated Electrospun Polycaprolactone/Polycaprolactone-Polyethyleneglycol-Polycaprolactone Blend Scaffold for Bone Tissue Engineering Applications
    (JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2013) Remya, KR; Joseph, J; Mani, S; John, A; Varma, HK; Ramesh, P
    The present work is a comparative evaluation of physical and biological properties of electrospun biodegradable fibrous scaffolds based on polycaprolactone (PCL) and its blend with polycaprolactone-polyethyleneglycol-polycaprolactone (CEC) with and without nanohydroxyapatite (nHAP) particles. The fiber morphology, porosity, surface wettability, and mechanical properties of electrospun PCL were distinctly influenced by the presence of both copolymer CEC and nHAP. The degradation in hydrolytic media affected both morphological and mechanical properties of the scaffolds and the tensile strength decreased by 58% for PCL, 83% for PCL/CEC, 36% for PCL/nHAP and 75% for PCL/CEC/nHAP in 90 days of PBS ageing. MU assay using mouse fibroblast L929 cells proved all the scaffolds to be non-cytotoxic. An overall enhanced performance was shown by PCL/CEC/nHAP scaffold in cell viability (LDH) and proliferation (Picogreen). Simultaneously, ELF assay of ALP activity (bone marker) confirmed the presence of osteogenic-induced Rabbit adipose-derived mesenchymal stem cells (ADMSCs) on all the scaffolds. In comparison, the results reveal the potential of the cytocompatible PCL/CEC/nHAP scaffold for the fabrication of living bony constructs for tissue engineering applications.
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    Osteogenesis of a bioactive ceramic calcium phospho silicate composite system in goat femur defect.
    (International Journal of Applied Ceramic Technology., 2011) John, A; Mani, S; Sandeep, G; Babu, SS; Lal, AV; Varma, HK
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    Osteogenesis of a Bioactive Ceramic-Calcium Phosphosilicate Composite System in Goat Femur Defect
    (INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2011) John, A; Mani, S; Gopalakrishnan, S; Babu, S; Lal, AV; Varma, H
    In spite of the array of synthetic bone grafts available, the pursuit for an ideal graft continues. In view of this, a synthetic bioactive calcium phosphosilicate composite (HABGS) has been developed combining the properties of hydroxyapatite and silicate system. The in vivo performance of HABGS granules in goat femur defect stimulated a favorable environment for de novo bone formation with faster resorption. The ceramic composite is attractive for its low Si content together with its negligible levels at implanted sites and vital organs postimplantation. Herein, we propose the safety and efficacy of this composite as a promising bone substitute.
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    Synthesis and physicochemical, in vitro and in vivo evaluation of an anisotropic, nanocrystalline hydroxyapatite bisque scaffold with parallel-aligned pores mimicking the microstructure of cortical bone
    (Journal of Tissue Engineering and Regenerative Medicine, 2013) Despang, F; Bernhardt, A; Lode, A; Dittrich, R; Hanke, T; Shenoy, SJ; Mani, S; John, A; Gelinsky, M