Browsing by Author "PAUL, W"

Now showing 1 - 7 of 7
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    ANTITHROMBOTIC ACTIVITY OF AN UNSATURATED FATTY-ACID PREPARATION - COMMENTS
    (THROMBOSIS RESEARCH, 1991) PAUL, W; SHARMA, CP
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    LIPOPROTEIN ADSORPTION ONTO MODIFIED CHITOSAN BEADS - PRELIMINARY-STUDY
    (BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY, 1993)
    Amoung the currently used LDL - apheresis techniques selective removal seems to be a better option. We have made a preliminary study on adsorption of LDL onto modified and bare chitosan and PVA beads. It seems that bare chitosan itself maybe an exellent adsorbent system for LDL. Further detailed studies are required to examine the specificity and selectivity in adsorption.
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    MODIFIED HYDROXYAPATITE MICROSPHERES AS IMMUNOADSORBENT FOR PLASMA PERFUSION - PRELIMINARY-STUDY
    (JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1995) PAUL, W; SHARMA, CP
    An improved solid-support, affinity immunoadsorbent suitable for extracorporeal perfusion of plasma is reported. This consists of hydroxyapatite microspheres coated with a thin layer of poly(vinyl alcohol) and immobilized phenylalanine as ligand. This adsorbent can remove IgG immunoglobulins specifically from plasma. The modified adsorbent may be used for direct hemoperfusion as a cheaper alternative to plasma adsorption therapy by eliminating cell separator for selective removal of antibodies belonging to immunoglobulin G class. (C) 1995 Academic Press, Inc.
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    POLYACRYLONITRILE-REINFORCED POLY(VINYL ALCOHOL) MEMBRANES - MECHANICAL AND DIALYSIS PERFORMANCE
    (JOURNAL OF APPLIED POLYMER SCIENCE, 1995) PAUL, W; SHARMA, CP
    Membranes used for hemodialysis should have good mechanical strength to withstand the maximum transmembrane pressure. Although crosslinked poly(vinyl alcohol) membrane has superior permeability to solutes, its wet breaking strength is low. Mechanical strength, dry and wet, of membranes made from crosslinked blendmers of poly(vinyl alcohol) and polyacrylonitrile was investigated. The possibilities of these membranes for the application as dialysis membranes were evaluated by estimating its solute permeabilities. The optimum membrane selected shows permeability and mechanical properties comparable with the commercial regenerated cellulose membrane. Polyelectrolyte grafting made the membrane more blood-compatible. (C) 1995 John Wiley and Sons, Inc.
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    POLYETHERURETHANEUREA REINFORCED POLY(VINYL ALCOHOL) DIALYSIS MEMBRANES - STUDIES ON PERMEABILITY AND MECHANICAL STRENGTH
    (BULLETIN OF MATERIALS SCIENCE, 1994) PAUL, W; SHARMA, CP
    Poly(vinyl alcohol) is a hydrogel which is extensively studied for a variety of biomedical applications. Membranes developed from crosslinked poly(vinyl alcohol) (PVA) is having excellent permeability to solutes. However its wet breaking strength is low. Polyetherurethaneurea (PEUU), having an excellent mechanical strength is blended with PVA as a reinforcement, and membranes developed are studied for its permeability and mechanical strength. The optimum membrane selected, is having permeability and wet breaking strength almost equal to the commercially available cellulose acetate membrane.
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    POLYVINYL-ALCOHOL DIALYSIS MEMBRANES - PERMEABILITY CHANGES DUE TO ASPIRIN RELEASE
    (ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992) SHARMA, CP; PAUL, W
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    PROTEIN-INTERACTION WITH TANTALUM - CHANGES WITH OXIDE LAYER AND HYDROXYAPATITE AT THE INTERFACE
    (JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1992)
    For metallic implants the surface nature is extremely important because blood and tissue interactions with metal depend upon it. Protein adsorption is the initial reaction that takes place when an implant comes in contact with blood or tissue. We attempted to coat different thicknesses of oxide layers and hydroxyapatite on tantalum and examined the changes in water contact angle and adsorption of albumin and fibrinogen. Protein adsorption studies were performed with I-125-labeled proteins. A decrease in water contact angle was observed as the oxide layer thickness of tantalum increased. Fibrinogen adsorption increased on oxide layer coated and hydroxyapatite coated surfaces, compared to bare tantalum.