Browsing by Author "Ramadas, M"
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Item Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats(JOURNAL OF MICROENCAPSULATION, 2000) Ramadas, M; Paul, W; Dileep, KJ; Anitha, Y; Sharma, CPAn oral formulation based on liposome encapsulated alginate-chitosan gel capsules was developed for insulin delivery for the treatment of diabetes. Liposome encapsulation helped to increase the encapsulation efficiency of insulin in alginate-chitosan capsules. This formulation delivers insulin in the neutral environment of the intestine, by-passing the acidic media in the stomach, with increased drug absorption and bioavailability. Oral administration of this formulation was found to reduce blood glucose levels when tested in diabetic rats.