Browsing by Author "Savlania, A"

Now showing 1 - 6 of 6
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    Adult coarctation of the aorta repaired with a prosthetic bypass and its long-term follow-up
    (EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014) Savlania, A; Parameshwarappa, SK; Agrawal, V; Unnikrishnan, M
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    An adolescent in acute respiratory distress with giant pulmonary arterio-venous malformation
    (EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2016) Veerbhadran, SP; Savlania, A; Pitchai, S; Unnikrishnan, M
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    Collateral venous drainage of solitary functioning left kidney with occluded renal vein following juxtarenal aortic aneurysm repair
    (JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS, 2015) Savlania, A; Parameshwarappa, SK; Viswanathan, S; Unnikrishnan, M
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    Dysphagia aortica due to penetrated aortic ulcer
    (EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2015) Savlania, A; Viswanathan, S; Pitchai, S; Unnikrishnan, M
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    Extra-anatomic neo-aorta for adult abdominal aortic coarctation
    (ANZ JOURNAL OF SURGERY, 2014) Savlania, A; Parameshwarappa, SK; Viswanathan, S; Raman, KT; Madathipat, U
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    Preclinical evaluation of hydrogel sealed fluropassivated indigenous vascular prosthesis
    (Indian Journal of Medical Research, 2018-03) Unnikrishnan, M; Umashankar, PR; Viswanathan, S; Savlania, A; Joseph, R; Muraleedharan, CV; Agrawal, V; Shenoy, SJ; Krishnan, LK; Mohanan, PV; Sabareeswaran, A
    Background & objectives: Polyethylene terephthalate (PET) graft, designed and developed at our institute for vascular reconstruction, is porous to promote optimal incorporation and neointima formation, requiring pre-clotting or biomodification by sealing the pores before implantation. The objective of this study was to characterize, test and perform preclinical evaluation of hydrogel (alginate dialdehyde cross-linked gelatin) sealed fluoropassivated PET vascular prosthesis in pig model, so as to avoid pre-clotting, for its safety and efficacy before employing the indigenous and less expensive graft for clinical use. Methods: Hydrogel sealed, fluoropassivated PET vascular prosthesis were tested for haemocompatibility and toxicity followed by small animal toxicology tests and in vivo experiments in pigs receiving implantation at thoracic aorta. All 33 animals received test as well as control grafts with a plan for phased explantation at 2, 12 and 26 weeks. All animals underwent completion angiogram at the end of procedure as well as before graft explantation. Results: Haemocompatibility tests for haemolysis and toxicity tests showed no adverse events in tested mice and rabbits. Completion angiogram showed intact anastamosis and patent graft in each animal in post-operative period and at explantation. Gross and histopathological examination showed wellencapsulated grafts, clean glistening neointima and no evidence of thrombus in both test and control grafts. Interpretation & conclusions: Hydrogel sealed, fluoropassivated PET vascular prosthesis was found non-toxic, haemocompatible and remained patent in in vivo studies at planned intervals.