Academic Day Presentations on 16.03.2024 at 8 AM by Department of Applied Biology
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Item Gross and histopathology of tissue - material interface in biocompatibility evaluation of biomaterials and medical devices- Part-I(SCTIMST, 2024-03-16) Sabareeswaran, ASafety evaluation is a critical component in medical device development. Biological evaluation should be carried out to identify the biological risk of biomaterials intended for medical devices after physicochemical characterization. Biocompatibility evaluation is a comprehensive terminology that broadly comprises in-vitro and in-vivo biological evaluations such as cytotoxicity tests, blood-material interactions, toxicological evaluation, etc. Testing for local effects after implantation is a major indicator for any candidate biomaterial safety, which is carried out in an appropriate animal model. The test sample is implanted into a site and animal species appropriate for the evaluation of the biological safety of the material. At the histopathology laboratory, we have tested metal, polymer, ceramic and composite biomaterials over the years as short and long-term implantation studies in rat and rabbit animal models. Gross and Histology images of compatible and non-biocompatible tissue response from intramuscular, subcutaneous and bone implantation in rabbit model and their relevance will be presented. The temporal variations of tissues responses and stages of foreign body reaction will be discussed. Specimen preparations, both soft and hard tissues starting from grossing, tissue processing, embedding, microtomy will be discussed. Gross and Histopathology evaluation of Chitra-TTK mechanical heart valve evaluated in-house in ovine(Sheep) and swine(Pig) model will be presented.Item Sleep Research Perspectives(SCTIMST, 2024-03-16) Kamalesh K, GuliaSleep is an indispensable component of our life. However, it is becoming a growing challenge to get good sleep in the current changing lifestyle, which is loaded with artificial light and several other factors. In the Division of Sleep Research, both basic and applied research are carried out to understand the mechanism and effects of restriction of different components of sleep on cognition and overall health in different age groups. The elegant data on sleep restriction during pregnancy on the neurocognitive development of offspring will be described. This facility, which started in 2009, is one of the unique, highly specialized, state-of-the-art sleep research facilities in the BMT wing. Sleep studies are conducted to explore non-pharmacological interventions to improve sleep quality based on electrophysiological parameters. The findings of pre-clinical research translating into applied research will be reflected through the current ongoing projects with an insight on future trends.