Long-term healing of mildly cross-linked decellularised bovine pericardial aortic patch
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Date
2016-08
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Publisher
JBMR-part B
Abstract
: Glutaraldehyde treated bovine pericardium is extensively
used in cardiovascular surgery. However, frequent
occurrence of failure modes, such as calcification and structural
failure, has hard pressed the need for finding an alternate
technology. Decellularized bovine pericardium is an
emerging technology. Mildly cross-linked decellularized
bovine pericardium promotes positive remodeling with insignificant
calcification and acute inflammation. In the present
study, mildly cross-linked decellularized bovine pericardium
was evaluated as a cardiovascular patch by studying mechanical
strength as well as graft remodeling, resistance to calcific
degeneration and inflammatory response using long duration
porcine aortic implantation. It was observed that decellularized
bovine pericardium, although thinner and less elastic
had equivalent tensile properties such as tensile strength and
stiffness when compared to commercially available
glutaraldehyde-treated bovine pericardium. It showed the
potential for site appropriate remodeling evidenced by host
cell incorporation, thinner neointima, graft degradation, and
neocollagenisation making it suitable for vascular patch
application, whereas glutaraldehyde-treated pericardium
failed to integrate with host tissue through timely degradation
and host cell incorporation or neocollagenization. Conversely,
it elicited persistent acute inflammation and
produced calcification. VC 2016 Wiley Periodicals, Inc. J Biomed
Mater Res Part B: Appl Biomater 00B: 000–000, 2016.
Description
Keywords
decellularised bovine pericardium, aortic patch, long-term healing
Citation
Umashankar P R, Sabareeswaran A, Shenoy S J. Long-term healing of mildly cross-linked decellularised bovine pericardial aortic patch. JBMR-part B. 2016.