Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T1-T2 MRI contrast agents
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Date
2016-10
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Scientific Reports
Abstract
Tetragonal (t)-LaVO4 has turned out to be a potential host for luminescent materials. Synthesis
of t-LaVO4 till date has been based on chelating effect of EDTA making it not ideal for bioimaging
applications. An alternative was proposed by us through the use of catechin. In recent times there is
interest for new MRI contrast agents that can through appropriate doping function both as MRI contrast
and optical/upconversion materials. It is generally believed that under appropriate doping, t-LaVO4
would be a better upconversion material than monoclinic (m)-LaVO4. Based on these postulations,
this work explores the use of gadolinium doped t-LaVO4 as an MRI contrast agent. From literature,
gadolinium oxide is a good T1 contrast agent. Through this work, using catechin as a template for the
synthesis of Gd doped t-LaVO4, we demonstrate the possible use as a T1 contrast agent. Interestingly,
as the catechin concentration changes, morphology changes from nanorods to square nanoplates
and spheres. In this process, a switch from T1 to T2 contrast agent was also observed. Under optimal
concentration of catechin, with a rod shaped Gd doped t-LaVO4 an r2/r1 value of 21.30 was observed.
Similarly, with a spherical shape had an r2/r1 value of 1.48 was observed.
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Citation
Vairapperumal T, Saraswathy A,. Ramapurath JS, Janardhanan SK , Unni NB . Catechin tuned magnetism of Gd-doped orthovanadate through morphology as T1-T2 MRI contrast agents. Scientific Reports. 2016;6:34976