Engineered Zinc Oxide Nanoparticles; Biological Interactions at the Organ Level
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Date
2016-12
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Journal Title
Journal ISSN
Volume Title
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Current Medicinal Chemistry
Abstract
Zinc oxide nanoparticles (ZnO NPs) are one of the widely used
nanoparticles with spectrum of application, in the areas like daily care products,
sensors, antibacterial agents, and biomedical sector. With extensive
application the risk of exposure at occupational and consumer level also increases.
Huge amount of data are available on the biointeraction of ZnO
NPs. Though the toxicity of ZnO NPs is attributed to particle dissolution
inside the cellular compartments and their ability to generate the reactive
oxygen species, the ambiguity prevails over the exact mechanism of toxicity.
The in vivo studies on different animal models and humans suggest different
level of toxicity in these organisms. However the synthetic route,
physiochemical properties of the nanoparticle, mode of exposure and nature of the test system
often influences these studies. Hence the study results vary and sometimes contradict on
one another. The current review focuses on the interaction of ZnO NPs with different organ
systems. It also points to the factors to be considered while undertaking such studies in order
to ensure reliability of the results
Description
Keywords
ZnO nanoparticle, organ toxicity, ROS, neurotoxicity, immune response.
Citation
1 Sruthi S, Mohanan PV. Engineered Zinc Oxide Nanoparticles; Biological Interactions at the Organ Level. Current Medicinal Chemistry. 2016;23:1-13.