Anaesthetic regimen for coronary stenting in porcine model
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Date
2006
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Publisher
INDIAN VETERINARY JOURNAL
Abstract
Coronary stent is one of the medical devices that is used in the treatment of localized atherosclerotic plaques in coronary artery. A suitable animal model is an essential step involved in stabilizing the safety and efficacy of implants. Swine is the animal model of choice for cardiovascular implantables (Francis et al., 1986; Martin et al., 1995 and Hughes, 1986), and is used as the animal model for coronary stent evaluation (Schulz et al., 2000). Since the normal porcine coronary artery is hypersensitive to surgical manipulations and anaesthetics (Michael et al., 1986), swine is prone to cardiac fibrillations and dysrhythmias. Halothane sensitizes the myocardium to endogenous catacholamines such as adrenaline, which can produce cardiac arrhythmias (Paddleford, 1984). An anesthetic technique found effective in performing coronary stenting with good results in 32 pigs is discussed in this article.
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Veterinary Sciences
Citation
83 ,5;486-489