A new generation of high flex life polyurethane urea for polymer heart valve-Studies on in vivo biocompatibility and biodurability
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Date
2009
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Abstract
Development of new generation high flex life polyurethane urea (HFL18-PU) with appropriate elastic modulus, biocompatibility, blood compatibility, resistant to calcification, and biodurability for the long-term use as cardiac device is still a challenge. This study reports the development of a fully aliphatic, ether-free physically cross-linked and low elastic modulus (6.841 +/- 0.27 MPa) polyurethane urea having hi vivo biostability, in vivo biocompatibility and high flex-life (721 +/- 30 million cycles) that can satisfy the requirements for the fabrication of tri-leaflet heart valve. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 192-205, 2009
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Biomaterials
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 89A; 1; 192-205