Modified polyacrylamide microspheres as immunosorbent

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dc.contributorPanikkar, B
dc.contributorHari, PR
dc.contributorSharma, CP
dc.date.accessioned2012-12-04T11:44:38Z
dc.date.available2012-12-04T11:44:38Z
dc.date.issued1997
dc.description.abstractExtracorporeal immunoadsorption system has been used for the specific removal of immunologically active substances from the blood. In this study, an attempt is made to utilise polyacrylamide microspheres as a matrix for immunoadsorption. Phenyl alanine is coupled onto the polymer beads using glutaraldehyde. These modified beads exhibit a high binding affinity for gamma-globulin compared to bare beads. The surface modified ones showed selective adsorption of immunoglobulins of IgG class. The C-3 adsorption pattern is not altered significantly upon modification. Modified beads are found to be less hemolytic after modification. However, more studies are to be conducted for the development of a hemoperfusion column based on this modified matrix.
dc.identifier.citationARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY. 25; 6; 541-550en_US
dc.identifier.urihttp://dx.doi.org/10.3109/10731199709117451
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/753
dc.publisherARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY
dc.subjectBiomaterials
dc.titleModified polyacrylamide microspheres as immunosorbent
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