Changes in polyurethane calcification due to antibiotics
No Thumbnail Available
Date
1996
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ARTIFICIAL ORGANS
Abstract
To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced calcification must be better understood. Calcification was examined on porous polyurethane incubated in metastable solutions of calcium phosphate, and the role of certain antibiotics in the medium was evaluated. It seems that certain aminoglycoside antibiotics can modify polyurethane surfaces and, subsequently, their mineralization process. In addition, these antibiotics may alter the calcium transport through polyurethanes. Therefore, it is conceivable that certain antibiotics can, in addition to producing their antibacterial effect, modulate surface calcium binding by changing the calcium mobilization and crystallization. Additional studies are needed to develop applications.
Description
Keywords
Biocompatibility
Citation
ARTIFICIAL ORGANS. 20; 7; 752-760