Superoxide anions mediate proliferative response in cardiac fibroblasts
No Thumbnail Available
Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
INDIAN JOURNAL OF MEDICAL RESEARCH
Abstract
The study was undertaken to examine whether superoxide anions mediate a proliferative response in cardiac fibroblasts. Cardiac fibroblasts isolated from newborn Wistar rats were exposed to superoxide anion generating system (hypoxanthine + xanthine oxidase) and its effect on cell growth was assessed. A stimulatory response on fibroblast proliferation was observed. The proportion of proliferating cells increased within 3 h of treatment compared to the control and the cell density after 96 h of exposure remained significantly high (P<0.0005). Inclusion of antioxidants neutralised the stimulatory response, fortifying the role of superoxide anions in cell proliferation. This observation indicates that superoxide anions can mediate a fibrotic reaction in the cardiac tissue.
Description
Keywords
Immunology; General & Internal Medicine; Research & Experimental Medicine
Citation
111 ,;127-132