Superoxide anions mediate proliferative response in cardiac fibroblasts

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dc.contributor.authorPreeta, R
dc.contributor.authorNair, RR
dc.date.accessioned2017-03-10T03:28:48Z
dc.date.available2017-03-10T03:28:48Z
dc.date.issued2000
dc.description.abstractThe study was undertaken to examine whether superoxide anions mediate a proliferative response in cardiac fibroblasts. Cardiac fibroblasts isolated from newborn Wistar rats were exposed to superoxide anion generating system (hypoxanthine + xanthine oxidase) and its effect on cell growth was assessed. A stimulatory response on fibroblast proliferation was observed. The proportion of proliferating cells increased within 3 h of treatment compared to the control and the cell density after 96 h of exposure remained significantly high (P<0.0005). Inclusion of antioxidants neutralised the stimulatory response, fortifying the role of superoxide anions in cell proliferation. This observation indicates that superoxide anions can mediate a fibrotic reaction in the cardiac tissue.
dc.identifier.citation111 ,;127-132en_US
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10510
dc.publisherINDIAN JOURNAL OF MEDICAL RESEARCH
dc.subjectImmunology; General & Internal Medicine; Research & Experimental Medicine
dc.titleSuperoxide anions mediate proliferative response in cardiac fibroblasts
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