ADENOSINE AND ATP - MUTUALLY EXCLUSIVE MODIFIERS OF THE KINETICS OF ADP-INDUCED AGGREGATION OF CALF-PLATELETS
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Date
1990
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Journal ISSN
Volume Title
Publisher
JOURNAL OF BIOSCIENCES
Abstract
Modulations of initial rate kinetics of ADP-induced aggregation of citrated calf platelet-rich plasma by adenosine and ATP were investigated employing a spectrophotometric platelet aggregation assay. The data were analysed according to the tenets of the sequential shape-change and interaction model of aggregation. Adenosine and ATP increased the slopes and intercepts of double-reciprocal plots of ADP-aggregation kinetics. Examination of their slope and intercept effects together with their effects individually and in combination, on aggregation rates, suggested that adenosine and ATP acted at multiple, nonoverlapping, sites.
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Life Sciences & Biomedicine - Other Topics
Citation
15 ,4;389-396