Pro-fibrogenic effects of magnesium deficiency in the cardiovascular system
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Date
2002
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Journal ISSN
Volume Title
Publisher
MAGNESIUM RESEARCH
Abstract
Magnesium deficiency is known to produce cardiovascular injury. A large body of experimental evidence supports the postulation that an immuno-inflammatory reaction and increased oxidative stress may damage the myocardium and vasculature in magnesium deficiency. Reparative/reactive fibrosis in response to the injury has, however, received little attention. Recent evidence from a rodent model of acute magnesium deficiency suggests that humoral factors may activate cardiac fibroblasts by a free radical-mediated mechanism and contribute to cardiac fibrogenesis. A similar mechanism may also promote cellular hyperplasia and increased matrix synthesis in the vasculature.
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Keywords
Cardiology
Citation
MAGNESIUM RESEARCH. 15; 40972; 307-315