Pro-fibrogenic effects of magnesium deficiency in the cardiovascular system

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dc.contributorShivakumar, K
dc.date.accessioned2012-12-04T11:45:00Z
dc.date.available2012-12-04T11:45:00Z
dc.date.issued2002
dc.description.abstractMagnesium deficiency is known to produce cardiovascular injury. A large body of experimental evidence supports the postulation that an immuno-inflammatory reaction and increased oxidative stress may damage the myocardium and vasculature in magnesium deficiency. Reparative/reactive fibrosis in response to the injury has, however, received little attention. Recent evidence from a rodent model of acute magnesium deficiency suggests that humoral factors may activate cardiac fibroblasts by a free radical-mediated mechanism and contribute to cardiac fibrogenesis. A similar mechanism may also promote cellular hyperplasia and increased matrix synthesis in the vasculature.
dc.identifier.citationMAGNESIUM RESEARCH. 15; 40972; 307-315en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/12635886
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/935
dc.publisherMAGNESIUM RESEARCH
dc.subjectCardiology
dc.titlePro-fibrogenic effects of magnesium deficiency in the cardiovascular system
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