Polyethylene glycol (PEG) modified bovine pericardium as a biomaterial: A comparative study on immunogenicity

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dc.contributorAravind, S
dc.contributorPaul, W
dc.contributorVasudev, SC
dc.contributorSharma, CP
dc.date.accessioned2012-12-04T11:44:53Z
dc.date.available2012-12-04T11:44:53Z
dc.date.issued1998
dc.description.abstractBioprosthetic heart valves made from glutaraldehyde (GA)-fixed porcine aortic valves or bovine pericardium (BP) are having some advantages over mechanical valves. However, their durability is low due to the calcification and immunological rejection. Study on immunogenicity is an important part in understanding the biocompatibility of materials. Polyethylene glycol (PEG) on pericardium can control biodegradation and calcification. Also, PEG exhibits low immunogenicity. We have studied the complement activation potential and the contribution of complement factors (biologic factors) on the calcification of PEG grafted pericardium samples and compared with standard (control) glutaraldehyde-treated pericardium samples. PEG-grafted BP activated using GA and carbodiimide (EDC) could be selected for further studies since complement activation and calcification observed on these samples has been relatively low.
dc.identifier.citationJOURNAL OF BIOMATERIALS APPLICATIONS. 13; 2; 158-165en_US
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/881
dc.publisherJOURNAL OF BIOMATERIALS APPLICATIONS
dc.subjectBiocompatibility
dc.titlePolyethylene glycol (PEG) modified bovine pericardium as a biomaterial: A comparative study on immunogenicity
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