Academic Day Presentations on 06.04.2024 by Department of Pathology

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Browsing Academic Day Presentations on 06.04.2024 by Department of Pathology by Issue Date

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    Epilepsy-associated lesions: Surgical Pathology
    (SCTIMST, 2024-04-06) Rajalakshmi, P
    Epilepsy is a complex disease and is caused by a variety of lesions that fall under various aetiologies such as malformative, genetic, infectious, metabolic, immune-mediated and neoplastic aetiologies. Patients’ evaluation and management require an interdisciplinary approach with the involvement of clinical assessment, electrophysiology, imaging and pathology. Definitive surgeries are offered to patients with poor response to anti-seizure medications and to those with a focal lesion. As Pathologists, we receive tissue samples from surgical resections of the epileptogenic focus. The most common lesions that are diagnosed histopathologically are hippocampal sclerosis, focal cortical dysplasias and neoplasms. This talk will give an overview of the various lesions that a neuropathologist encounters in the surgical samples of epilepsy-related disorders. How the samples are processed and assessed will be illustrated.
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    Utility of interphase fluorescent in situ hybridization for diagnosis of brain tumors
    (SCTIMST, 2024-04-06) Deepti, AN
    Brain tumours are classified as per the 5th edition of the WHO classification of tumours of the central nervous system. This latest edition of CNS tumors incorporates molecular features along with the conventional histology leading to “histomolecular” classification. Interphase Fluorescent in situ hybridization (iFISH) is a useful ancillary technique to the pathologist. It is useful to identify gene deletions, amplifications and rearrangements. Fluorescent-tagged FISH probes are hybridized to formalin-fixed paraffin-embedded sections on glass slides and the nuclei are observed under a fluorescent microscope. iFISH is particularly useful in a resource constrained setting where more advanced aids such as methylation profiling and targeted panels are not readily available. The iFISH technique performed in the pathology department will be discussed and the utility of iFISH in neuro-oncology diagnostics will be illustrated through a case-based discussion.