Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats
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Date
2017-04
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Materials Science and Engineering
Abstract
Although the toxicity/biocompatibility of hydroxyapatite nanoparticles (nano HA), a prospective nano biomaterial
is extensively studied, its interaction on biological systems following chronic exposure is less exploited. In the
present study, Wistar rats were given various concentrations of nano HA in the diet to determine the chronic toxicity
and potential carcinogenicity. Altogether 140 rats were used for the study under various administration dosages
along with control. The animals were sacrificed after 12 months of controlled continuous dosing. All in-life
parameters, including body weight, food consumption, clinical observations, survival, biochemical and hematology,
were unaffected by the chronic exposure of nano HA orally. Similarly, gross and histopathological evaluation
was also unchanged following exposure to nano HA. No evidence of nano HA-related lesions or Nano HA-induced
neoplasia was suggested in this rodent bioassay study.
Description
Keywords
Nanomaterials, Hydroxyapatite, Chronic toxicity, Histopathology
Citation
. Remya NS, Syama S, Sabareeswaran A, Mohanan PV. Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats. Materials Science and Engineering C. 2017;76:518-27