Adsorption of human IgG on Cu2+-immobilized cellulose affinity membrane: Preliminary study
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Date
2000
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
Abstract
Immobilized metal ion affinity chromatography (IMAC) is widely used. Transition metal ions have a high affinity to some peptide sequences. We have studied the selective adsorption of human IgG from a mixture of albumin, gamma-globulin, fibrinogen, and IgG onto Cu2+ ion-immobilized cellulose membrane. Although Cu2+ ligand is selective to IgG, in general gamma-globulins also are adsorbed. The simplicity and lower cost of Cu2+ ion-immobilized cellulose membranes may be useful for removing IgG from blood. (C) 2000 John Wiley & Sons, Inc.
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Biocompatibility
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. 50; 2; 110-113