Application of molecularly imprinted polymer as a drug retaining matrix
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Date
1997
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
ANGEWANDTE MAKROMOLEKULARE CHEMIE
Abstract
Copolymerization by gamma irradiation of 2-hydroxyethyl methacrylate with ethylene glycol dimethacrylate in the presence of hydrocortisone as model drug gave a molecular imprinted polymer (MIP). The hydrocortisone was removed from the matrix with chloroform and incorporated again from methanol solution. Release data show that 96% of the incorporated drug is retained after 30 days storage in a methanol/water (3:1 v/v) mixture. In comparison with hydrocortisone, only a small quantity of testosterone is absorbed by the matrix.
Description
Keywords
Polymer Science
Citation
246 ,;65-69